webPIPSA -- Protein Interaction Property Similarity Analysis
URL:
What you can do:
A web server for the comparison of protein interaction properties.
Highlights:
- Protein molecular interaction fields are key determinants of protein functionality.
- PIPSA (Protein Interaction Property Similarity Analysis) is a procedure to compare and analyze protein molecular interaction fields, such as the electrostatic potential.
- PIPSA may assist in protein functional assignment, classification of proteins, the comparison of binding properties and the estimation of enzyme kinetic parameters.
- webPIPSA is a web server that enables the use of PIPSA to compare and analyze protein electrostatic potentials.
- While PIPSA can be run with downloadable software (see http://projects.eml.org/mcm/software/pipsa), webPIPSA extends and simplifies a PIPSA run. This allows non-expert users to perform PIPSA for their protein datasets.
- With input protein coordinates, the superposition of protein structures, as well as the computation and analysis of electrostatic potentials, is automated.
- The results are provided as electrostatic similarity matrices from an all-pairwise comparison of the proteins which can be subjected to clustering and visualized as epograms (tree-like diagrams showing electrostatic potential differences) or heat maps.
Keywords:
- protein molecular interaction fields
- protein interaction properties
- binding properties
- enzyme kinetic parameters
- protein electrostatic interaction properties
Literature & Tutorials:
This record last updated: 07-24-2008