PhosphoPOINT -- a comprehensive human kinase interactome and phospho-protein database
What you can do:
Uncover novel substrates for specific kinases.
Highlights:
- PhosphoPOINT is a collection of 4195 phospho-proteins with a total of 15 738 phosphorylation sites.
- It annotates the interactions among kinases, with their down-stream substrates and with interacting (phospho)-proteins to modulate the kinase-substrate pairs.
- PhosphoPOINT implements various gene expression profiles and Gene Ontology cellular component information to evaluate each kinase and their interacting (phospho)-proteins/substrates.
- Integration of cSNPs that cause amino acids change with the proteins with the phosphoprotein dataset reveals that 64 phosphorylation sites result in a disease phenotypes when changed; the linked phenotypes include schizophrenia and hypertension.
- PhosphoPOINT also provides a search function for all phospho-peptides using about 300 known kinase/phosphatase substrate/binding motifs.
- Altogether, PhosphoPOINT provides robust annotation for kinases, their downstream substrates and their interaction (phospho)-proteins and this should accelerate the functional characterization of kinomemediated signaling.
Keywords:
- Phosphoproteins
- Phosphorylation
- Phosphotransferases
- Protein Binding
- Protein Interaction Mapping
- Kinase
- phospho-protein
Literature & Tutorials:
This record last updated: 11-25-2008