SuperSite -- Ligand Binding Site Database
What you can do:
Look at protein structure from a ligand and binding site perspective.
Highlights:
- SuperSite combines the structural information with various tools for the analysis of molecular recognition.
- It contains 8000 metabolites including 1300 drugs, bound to about 290,000 different receptor binding sites.
- The analysis tools include the highlighting of evolutionary conserved receptor residues, the marking of putative binding pockets and the superpositioning of different binding sites of the same ligand.
- User-defined compounds can be edited or uploaded and will be superimposed with the most similar co-crystallized ligand.
- The user can examine all results online with the molecule viewer Jmol.
- An implemented search algorithm allows the screening of uploaded proteins, in order to detect potential drug binding sites, which are similar to known binding pockets.
- The huge data set of target-bound compounds in combination with the provided analysis tools allow to inspect the characteristics of molecular recognition, especially for drug target interactions.
Keywords:
- ligand
- binding site
- protein structure
- drug target interaction
- binding site prediction
- drug compound
- metabolite
- molecular recognition
Literature & Tutorials:
This record last updated: 03-20-2009