HotPoint -- HotPoint: hot spot prediction server for protein interfaces
What you can do:
Predict areas in a protein sequence which contribute more to the binding free energy.
Highlights:
- HotPoint is a web server which predicts hot spots in protein interfaces using an empirical model.
- The empirical model incorporates a few simple rules consisting of occlusion from solvent and total knowledge-based pair potentials of residues.
- The prediction model is computationally efficient and achieves high accuracy of 70%.
- The input to the HotPoint server is a protein complex and two chain identifiers that form an interface.
- The server provides the hot spot prediction results, a table of residue properties and an interactive 3D visualization of the complex with hot spots highlighted.
- Results are also downloadable as text files.
- This web server can be used for analysis of any protein-protein interface which can be utilized by researchers working on binding sites characterization and rational design of small molecules for protein interactions.
Keywords:
- hot spot
- binding free energy
- protein docking site
- docking site
- protein interaction site
- protein-protein interaction
Literature & Tutorials:
This record last updated: 06-04-2010