RegPhos -- REGulatory Network in Protein PHOSphorylation
What you can do:
Find information about the protein kinase-substrate phosphorylation network in humans.
Highlights:
- RegPhos is a knowledgebase developed to integrate experimentally verified protein phosphorylation data and protein-protein interaction data for constructing the protein kinase-substrate phosphorylation networks in human.
- A total of 21,110 experimental verified phosphorylation sites within 5092 human proteins are collected.
- Only 4138 phosphorylation sites (∼20%) have the annotation of catalytic kinases from public domain.
- In order to fully investigate how protein kinases regulate the intracellular processes, a published kinase-specific phosphorylation site prediction tool, named KinasePhos is incorporated for assigning the potential kinase.
- The web-based system, RegPhos, can let users input a group of human proteins; consequently, the phosphorylation network associated with the protein subcellular localization can be explored.
- Time-coursed microarray expression data is subsequently used to represent the degree of similarity in the expression profiles of network members.
Keywords:
- protein kinase
- kinase-substrate phosphorylation
- phosphorylation site
- protein-protein interaction
- PPI
Literature & Tutorials:
This record last updated: 06-14-2011