SIFT -- predicting amino acid changes that affect protein function

What you can do:
Predict what amino acid substitutions will affect protein function.
Highlights:
  • Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding regions.
  • SIFT (Sorting Intolerant From Tolerant) is a program that predicts whether an amino acid substitution affects protein function so that users can prioritize substitutions for further study.
  • It is shown that SIFT can distinguish between functionally neutral and deleterious amino acid changes in mutagenesis studies and on human polymorphisms.
Keywords:
  • Single Nucleotide polymorphisms
  • SNPs
  • Single Nucleotide polymorphism analysis tool
  • SNPs analysis tool
  • Single Nucleotide polymorphism analysis tool
  • SNPs analysis tool
  • SNP mutation analysis tool
  • protein function prediction tool
  • amino acid substitution effect prediction tool
  • human mutagenesis
  • human genetic variations
  • protein sequence alignment tool
This record last updated: 06-17-2005

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