PROTEUS2 -- a web server for comprehensive protein structure prediction and structure-based annotation

What you can do:
Supports comprehensive protein structure prediction and structure-based annotation.
Highlights:
  • PROTEUS2 accepts either single sequences (for directed studies) or multiple sequences (for whole proteome annotation) and predicts the secondary and, if possible, tertiary structure of the query protein(s).
  • Unlike most other tools or servers, PROTEUS2 bundles signal peptide identification, transmembrane helix prediction, transmembrane beta-strand prediction, secondary structure prediction (for soluble proteins) and homology modeling (i.e. 3D structure generation) into a single prediction pipeline.
  • Using a combination of progressive multi-sequence alignment, structure-based mapping, hidden Markov models, multi-component neural nets and up-to-date databases of known secondary structure assignments, PROTEUS is able to achieve among the highest reported levels of predictive accuracy for signal peptides (Q2 = 94%), membrane spanning helices (Q2 = 87%) and secondary structure (Q3 score of 81.3%).
  • PROTEUS2's homology modeling services also provide high quality 3D models that compare favorably with those generated by SWISS-MODEL and 3D JigSaw (within 0.2 A RMSD).
  • The average PROTEUS2 prediction takes approximately 3 min per query sequence.
Keywords:
  • protein structure prediction
  • protein structure-based annotation
  • whole proteome annotation
  • secondary structure prediction
  • signal peptide identification
  • transmembrane helix prediction
  • transmembrane beta-strand prediction
  • homology modeling
This record last updated: 07-23-2008
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