Estimate frequencies of single-nucleotide polymorphism (SNP) haplotypes from DNA pools.
Highlights:
Poool can efficiently estimate haplotype frequencies from DNA pools with arbitrarily large sizes.
The algorithm works equally well for large pools with sizes up to hundreds or thousands and for pools with sizes as small as one or two individuals.
The computational complexity of the PoooL algorithm is independent of pool sizes, and the computational efficiency for large pools is thus substantially improved over existing estimating methods.
