PROTOGENE -- turning amino acid alignments into bona fide CDS nucleotide alignments
What you can do:
Back translate protein multiple sequence alignments.
Highlights:
- Protogene is a server that can turn a protein multiple sequence alignment into the equivalent alignment of the original gene coding DNA.
- Protogene relies on a pipeline where every initial protein sequence is BLASTed against RefSeq or NR.
- The annotation associated with potential matches is used to identify the gene sequence which is then aligned with the query protein using Exonerate in order to extract a coding nucleotide sequence matching the original protein.
- Protogene can handle protein fragments and will return every CDS coding for a given protein, even if they occur in different genomes.
Keywords:
- protein multiple sequence alignment back translation tool
Literature & Tutorials:
This record last updated: 08-03-2006