TransfactomeDB -- a resource for exploring the nucleotide sequence specificity and condition-specific regulatory activity of trans-acting factors
What you can do:
Find information about the nucleotide sequence specificity of trans-acting factors (TFs) in yeast.
Highlights:
- The Yeast Transfactome Database is a repository of sequence specificity models and condition-specific regulatory activities for a large number of DNA- and RNA-binding proteins in Saccharomyces cerevisiae.
- The sequence specificities in TransfactomeDB, represented as position-specific affinity matrices (PSAMs), are directly estimated from genomewide measurements of TF-binding using a previously published MatrixREDUCE algorithm, which is based on a biophysical model.
- For each mRNA expression profile in the NCBI Gene Expression Omnibus, a sequence-based regression analysis was used to estimate the post-translational regulatory activity of each TF for which a PSAM is available.
- The trans-factor activity profiles across multiple experiments available in TransfactomeDB allow the user to explore potential regulatory roles of hundreds of TFs in any of thousands of microarray experiments.
Keywords:
- Saccharomyces cerevisiae
- yeast
- trans-acting factor
- trans factor
- gene regulatory network
- post-translational activity
- post-translation
- DNA-binding proteins
- RNA-binding proteins
Literature & Tutorials:
This record last updated: 03-03-2008